What causes intermittent airflow obstruction in asthma?

Intermittent airflow obstruction in asthma is primarily caused by mucus plug formation. In asthma, the airways become inflamed and hyper-responsive due to various triggers, leading to excessive production of mucus. This mucus can accumulate and form plugs in the airways, obstructing airflow and causing symptoms such as wheezing, coughing, and shortness of breath. These symptoms typically occur episodically, aligning with the definition of intermittent airflow obstruction.

Mucus plugs play a crucial role in the pathophysiology of asthma, as they can obstruct the airways during an asthma attack, contributing to the characteristic reversible airflow limitation that defines the condition. Addressing mucus production and removal is a key therapeutic focus in managing asthma and alleviating symptoms.