What is a noted adverse effect of leukotriene receptor antagonists?

Leukotriene receptor antagonists, such as montelukast, are primarily used to manage asthma symptoms and allergic rhinitis. One notable adverse effect associated with their use is the occurrence of neuropsychiatric events. These events can range from mood changes, agitation, insomnia, anxiety, and, in some rare cases, suicidal thoughts or actions.

The mechanism by which these neuropsychiatric effects occur is not fully understood, but patients and caregivers are typically advised to monitor for any mood-related changes, especially during the initiation of treatment or following a dosage change. The importance of recognizing these potential side effects has led regulatory agencies to emphasize the need for awareness among healthcare providers and patients alike.

In contrast, dry throat, increased appetite, and joint pain are not well-documented as significant adverse effects specific to leukotriene receptor antagonists. While patients might experience a variety of side effects from different medications, the evidence supporting the association of neuropsychiatric events with leukotriene receptor antagonists is notably recognized and warrants careful monitoring.