Which adverse effects are commonly associated with rapid withdrawal from systemic corticosteroids?

The correct answer highlights adrenal insufficiency as a key adverse effect associated with rapid withdrawal from systemic corticosteroids. When a patient has been on corticosteroid therapy for an extended period, the body's normal adrenal gland function may be suppressed. This happens because the body becomes reliant on the external corticosteroids to regulate various functions, including the body’s response to stress.

When corticosteroid use is abruptly ceased, the body may not be able to produce sufficient levels of cortisol immediately, leading to symptoms of adrenal insufficiency. These symptoms can include fatigue, weakness, low blood pressure, and hypoglycemia. Such adverse effects are particularly concerning during periods of physical stress, as the body may not be able to mount an adequate response.

Weight gain, while a concern with long-term use of corticosteroids, is not directly related to withdrawal. Hypotension can occur in various situations but is more closely associated with adrenal insufficiency rather than as a direct consequence of corticosteroid withdrawal. Respiratory depression is typically more associated with other medications or conditions rather than the cessation of corticosteroids. Thus, focusing on adrenal insufficiency emphasizes the critical nature of tapering corticosteroids properly to allow the adrenal glands to resume normal function.